12/12/08

Review of alpha-1 antitrypsin deficiency and hepatopulmonary syndrome

Review articles:
Gary Rachelefsky, D. Kyle Hogarth. Issues in the diagnosis of [alpha]1-antitrypsin deficiency, J Allergy Clin Immun. April 2008;121:833-838.

Kohnlein T, Welte T. Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment. American J Med. 2008;121: 3-9.


Article on hepatic involvement in pulmonary diseases (AT deficiency, sarcoidosis):
Layden TJ, et al. Hepatic manifestations of pulmonary diseases. Clinics in Liver Disease. 2002;6:969-979.


Review on hepatopulmonary syndrome and related letter on platypnea:
Hepatopulmonary syndrome--a liver-induced lung vascular disorder. N Engl J Med. 2008 May 29;358:2378-87.
The hepatopulmonary syndrome. N Engl J Med. 2008 Aug 21;359:866-867.

12/11/08

What are the clinical features of Legionnaires' disease?

Review article on Legionella infection (includes discussion of sensitivity of urine antigen test)

Diederen BMW. Legionella spp. and Legionnaires' disease. J Infect Dis. 2008;56 (1):1-12

12/4/08

When did blood banks begin testing donated blood for hepatitis C?

Excerpt from Mandell, Douglas, and Bennett's: Principles and Practice of Infectious Diseases,6th ed., Chapter 112, states that donors were screened for risk of
blood-borne viral infections in the 1980s and blood was tested for
HCV-specific antibodies beginning in May 1990

See also Donahue JG, et al: The declining risk of post-transfusion hepatitis C virus infection. N Engl J Med 1992; 327:369-373.