3 RCTs identified in Pubmed - Rifaximin & lactulose appear to be similar in efficacy
Comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized study.
Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial.
Double-blind, double-dummy comparison between treatment with rifaximin and lactulose in patients with medium to severe degree hepatic encephalopathy
